For the past decade, the Temasek Foundation-NUS Programme for Leadership in University Management (TF-NUS PLUM) has been a vital platform for Asian university leaders to engage in dialogue and exchange insights on latest trends, developments, and challenges faced by institutes of higher education. As technological advances in the field of Artificial Intelligence (AI) continue to reshape the ways in which societies function, universities must adeptly navigate this rapid shift and critically examine its impact on their roles as premier institutions of knowledge and research. Against this backdrop, it is timely to reflect on universities’ responsibility to provide an environment conducive to the holistic development of the individuals we are entrusted to nurture – manifesting in both a vibrant student life and the essential resources to support the mental wellness of those in our communities.